解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Within the context of increasing antimalarial costs and or decreasing malaria transmission, the importance of limiting antimalarial treatment to only those confirmed as having malaria parasites becomes paramount. This motivates for this assessment of the cost-effectiveness of routine use of rapid diagnostic ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-176
更新日期:2008-09-15 00:00:00
abstract:BACKGROUND:Plasmodium vivax is estimated to affect 75 million people annually. It is reportedly absent, however, from west and central Africa due to the high prevalence of the Duffy negative phenotype in the indigenous populations. Despite this, non-African travellers consistently return to their own countries with P. ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-174
更新日期:2008-09-11 00:00:00
abstract:BACKGROUND:The current status of insecticide resistance and the underlying resistance mechanisms were studied in the major vector of malaria, Anopheles culicifacies, and the secondary vector, Anopheles subpictus in five districts (Anuradhapura, Kurunegala, Moneragala, Puttalam and Trincomalee) of Sri Lanka. Eight other...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-168
更新日期:2008-08-28 00:00:00
abstract:BACKGROUND:Early diagnosis and prompt treatment including appropriate home-based treatment of malaria is a major strategy for malaria control. A major determinant of clinical outcome in case management is compliance and adherence to effective antimalarial regimen. Home-based malaria treatment with inappropriate medicin...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-143
更新日期:2008-07-29 00:00:00
abstract:BACKGROUND:Despite the abundance of studies conducted on the role of mosquitoes in malaria transmission, the biology and interaction of Plasmodium with its insect host still holds many mysteries. This paper provides the first study to follow the sporogonic cycle of Plasmodium vivax in a wild insecticide-resistant mysor...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-131
更新日期:2008-07-15 00:00:00
abstract:BACKGROUND:Falciparum malaria remains a major occupational illness that accounts for several deaths per year and numerous lost working days among the expatriate population, working or living in high-risk malarious areas. Compliance to preventive strategies is poor in travellers, especially business travellers, expatria...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-128
更新日期:2008-07-14 00:00:00
abstract:BACKGROUND:Malaria presents a diagnostic challenge in tribal belt of central India where two Plasmodium species, Plasmodium falciparum and Plasmodium vivax, are prevalent. In these areas, rapid detection of the malaria parasites and early treatment of infection remain the most important goals of disease management. The...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-126
更新日期:2008-07-11 00:00:00
abstract:BACKGROUND:The Duffy-binding protein II of Plasmodium vivax (PvDBPII) has been considered as an attractive target for vaccine-mediated immunity despite a possible highly polymorphic nature. Among seven PvDBP domains, domain II has been shown to exhibit a high rate of nonsynonymous polymorphism, which has been suggested...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-112
更新日期:2008-06-26 00:00:00
abstract:BACKGROUND:The level of antibodies against PfEMP1 is routinely quantified by the conventional microtitre enzyme-linked immunosorbent assay (ELISA). However, ELISA only measures one analyte at a time and requires a relatively large plasma volume if the complete antibody profile of the sample is to be obtained. Furthermo...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-108
更新日期:2008-06-12 00:00:00
abstract:BACKGROUND:Plasmodium vivax is a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to the Plasmodium spp. trophozoite, the stage when haemoglobin catabolism is maximal. H...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-94
更新日期:2008-05-27 00:00:00
abstract:BACKGROUND:Aggregated haemozoin crystals within malaria-infected erythrocytes confer susceptibility of parasitized cells to a magnetic field. Here the utility of this method for diagnosis of human malaria is evaluated in a malaria-endemic region of Papua New Guinea (PNG). METHODS AND FINDINGS:Individuals with Plasmodi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-66
更新日期:2008-04-25 00:00:00
abstract:BACKGROUND:Intermittent preventive (or presumptive) treatment of infants (IPTi), the administration of a curative anti-malarial dose to infants whether or not they are known to be infected, is being considered as a new strategy for malaria control. Five of the six trials using sulphadoxine-pyrimethamine (SP) for IPTi s...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-54
更新日期:2008-04-03 00:00:00
abstract:BACKGROUND:Malaria represents a huge burden for the health care services across Africa. Describing malaria attending health services contributes to quantify the burden and describe the epidemiology and clinical presentation. METHODS:Retrospective analysis of data collected through the Manhiça morbidity surveillance sy...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-36
更新日期:2008-02-26 00:00:00
abstract:BACKGROUND:It is estimated that over 70% of patients with suspected malaria in sub-Saharan Africa, diagnose and manage their illness at home without referral to a formal health clinic. Of those patients who do attend a formal health clinic, malaria overdiagnosis rates are estimated to range between 30-70%. METHODS:Thi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-33
更新日期:2008-02-18 00:00:00
abstract:BACKGROUND:Kenya recently changed its antimalarial drug policy to a specific artemisinin-based combination therapy (ACT), artemether-lumefantrine (AL). New national guidelines on the diagnosis, treatment and prevention were developed and disseminated to health workers together with in-service training. METHODS:Between...
journal_title:Malaria journal
pub_type: 杂志文章,多中心研究
doi:10.1186/1475-2875-7-29
更新日期:2008-02-05 00:00:00
abstract:BACKGROUND:Following the recognition that morbidity and mortality due to malaria had dramatically increased in the last three decades, in 2002 the government of Zambia reviewed its efforts to prevent and treat malaria. Convincing evidence of the failing efficacy of chloroquine resulted in the initiation of a process th...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-25
更新日期:2008-01-29 00:00:00
abstract:BACKGROUND:The Kilombero Valley is a highly malaria-endemic agricultural area in south-eastern Tanzania. Seasonal flooding of the valley is favourable to malaria transmission. During the farming season, many households move to distant field sites (shamba in Swahili) in the fertile river floodplain for the cultivation o...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-7
更新日期:2008-01-09 00:00:00
abstract:BACKGROUND:The susceptibility of anopheline mosquito species to Plasmodium infection is known to be variable with some mosquitoes more permissive to infection than others. Little work, however, has been carried out investigating the susceptibility of major malaria vectors to geographically diverse tropical isolates of ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-139
更新日期:2007-10-24 00:00:00
abstract:BACKGROUND:The malaria vector Anopheles gambiae is polymorphic for chromosomal inversions on the right arm of chromosome 2 that segregate nonrandomly between assortatively mating populations in West Africa. One such inversion, 2Rj, is associated with the BAMAKO chromosomal form endemic to southern Mali and northern Gui...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-133
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:The objective of this work was to develop a model to predict malaria incidence in an area of unstable transmission by studying the association between environmental variables and disease dynamics. METHODS:The study was carried out in Karuzi, a province in the Burundi highlands, using time series of monthly ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-129
更新日期:2007-09-24 00:00:00
abstract:BACKGROUND:Malaria was endemic in the Rhône-Alpes area of eastern France in the 19th century and life expectancy was particularly shortened in Alpine valleys. This study was designed to determine how the disease affected people in the area and to identify the factors influencing malaria transmission. METHODS:Demograph...
journal_title:Malaria journal
pub_type: 历史文章,杂志文章
doi:10.1186/1475-2875-6-115
更新日期:2007-08-29 00:00:00
abstract:BACKGROUND:A previous study showed for Anopheles gambiae s.s. a gradation of feeding preference on common plant species growing in a malaria holoendemic area in western Kenya. The present follow-up study determines whether there is a relationship between the mosquito's preferences and its survival and fecundity. METHO...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-113
更新日期:2007-08-21 00:00:00
abstract::The National Vector Borne Disease Control Programme (NVBDCP) of the Ministry of Health, Government of India is reporting about 2 million parasite positive cases each year, although case incidence is 30-fold or more under-estimated. Forty five to fifty percent of Plasmodium infections are caused by Plasmodium falciparu...
journal_title:Malaria journal
pub_type: 社论
doi:10.1186/1475-2875-6-105
更新日期:2007-08-07 00:00:00
abstract:BACKGROUND:Intermittent preventive treatment with sulphadoxine-pyrimethamine (IPT-SP) is currently the recommended regimen for prevention of malaria in pregnancy in endemic areas. This study sets out to evaluate the effectiveness of IPT-SP in the prevention of maternal and placental malaria in parturient mothers in Iba...
journal_title:Malaria journal
pub_type: 临床试验,杂志文章
doi:10.1186/1475-2875-6-88
更新日期:2007-07-06 00:00:00
abstract:BACKGROUND:Mosquito larval control may prove to be an effective tool for incorporating into integrated vector management (IVM) strategies for reducing malaria transmission. Here the efficacy of microbial larvicides against Anopheles gambiae s.l. was tested in preparation for a large-scale larviciding programme in The G...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-76
更新日期:2007-06-07 00:00:00
abstract:BACKGROUND:Larviciding is a key strategy used in many vector control programmes around the world. Costs could be reduced if larvicides could be manufactured locally. The potential of natural products as larvicides against the main African malaria vector, Anopheles gambiae s.s was evaluated. METHODS:To assess the larvi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-63
更新日期:2007-05-22 00:00:00
abstract:BACKGROUND:Data concerning antimalarial combination treatment for uncomplicated malaria in Madagascar are largely lacking. Randomized clinical trial was designed to assess therapeutic efficacies of chloroquine (CQ), amodiaquine (AQ), sulphadoxine-pyrimethamine (SP), amodiaquine plus sulphadoxine-pyrimethamine combinati...
journal_title:Malaria journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1475-2875-6-65
更新日期:2007-05-22 00:00:00
abstract:BACKGROUND:Global malaria control strategies highlight the need to increase early uptake of effective antimalarials for childhood fevers in endemic settings, based on a presumptive diagnosis of malaria in this age group. Many control programmes identify private medicine sellers as important targets to promote effective...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-57
更新日期:2007-05-10 00:00:00
abstract:BACKGROUND:Standard methods for defining clinical malaria in intervention trials in endemic areas do not guarantee that efficacy estimates will be unbiased, and do not indicate whether the intervention has its effect by modifying the force of infection, the parasite density, or the risk of pathology at given parasite d...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-53
更新日期:2007-05-02 00:00:00
abstract:BACKGROUND:Polymorphism in the pfcrt gene underlies Plasmodium falciparum chloroquine resistance (CQR), as sensitive strains consistently carry lysine (K), while CQR strains carry threonine (T) at the codon 76. Previous studies have shown that microsatellite (MS) haplotype variation can be used to study the evolution o...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-34
更新日期:2007-03-21 00:00:00
abstract:BACKGROUND:Coverage of vulnerable groups with insecticide-treated nets (ITNs) in Ghana, as in the majority of countries of sub-Saharan Africa is currently low. A voucher scheme was introduced in Volta Region as a possible sustainable delivery system for increasing this coverage through scale-up to other regions. Succes...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-14
更新日期:2007-02-02 00:00:00
abstract:BACKGROUND:Artemisinin-derivative formulations are now widely used to treat falciparum malaria. However, the dry powder suspensions developed for children are few and/or are of poor quality. In addition to the active compound, the presence of a suitable preservative in these medicines is essential. In this study, an ev...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-12
更新日期:2007-01-26 00:00:00
abstract:BACKGROUND:Ethnographic studies from East Africa suggest that cerebral malaria and anaemia are not classified in local knowledge as malaria complications, but as illnesses in their own right. Cerebral malaria 'degedege' has been most researched, in spite of anaemia being a much more frequent complication in infants, an...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-5-111
更新日期:2006-11-20 00:00:00
abstract:BACKGROUND:Antananarivo, the capital of Madagascar, is located at an altitude of over 1,200 m. The environment at this altitude is not particularly favourable to malaria transmission, but malaria nonetheless remains a major public health problem. The aim of this study was to evaluate exposure to malaria in the urban po...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-5-106
更新日期:2006-11-10 00:00:00
abstract:BACKGROUND:Surprisingly little is known about the geographical overlap between malaria and other tropical diseases, including helminth infections. This is despite the potential public health importance of co-infection and synergistic opportunities for control. METHODS:Statistical models are presented that predict the ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-5-99
更新日期:2006-11-03 00:00:00
abstract:BACKGROUND:The standard in vitro protocol currently in use for drug testing against Plasmodium falciparum, based on the incorporation of the purine [3H]-hypoxanthine, has two serious drawbacks. Firstly it is unsuitable for the testing of drugs that directly or indirectly impact on purine salvage or metabolism. Secondly...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-5-95
更新日期:2006-10-31 00:00:00
abstract:BACKGROUND:A high prevalence of spherocytes was detected in blood smears of children enrolled in a case control study conducted in the malaria holoendemic Lake Victoria basin. It was speculated that the spherocytes reflect intraerythrocytic removal of malarial parasites with a concurrent removal of RBC membrane through...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-5-64
更新日期:2006-07-31 00:00:00
abstract:BACKGROUND:Knowledge of the ecological differences between the molecular forms of Anopheles gambiae and their sibling species, An. arabiensis might lead to understanding their unique contribution to disease transmission and to better vector control as well as to understanding the evolutionary forces that have separated...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-5-19
更新日期:2006-03-22 00:00:00
abstract:BACKGROUND:Mutations in the haemoglobin beta-globin (HbB) and glucose-6-phosphate dehydrogenase (G6PD) genes cause widespread human genetic disorders such as sickle cell diseases and G6PD deficiency. In sub-Saharan Africa, a few predominant polymorphic variants of each gene account for a majority of these deficiencies....
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-4-61
更新日期:2005-12-15 00:00:00
abstract:BACKGROUND:Severe anaemia can develop in the aftermath of Plasmodium falciparum malaria because of protracted bone marrow suppression, possibly due to residual subpatent parasites. MATERIALS AND METHODS:Blood was collected from patients with recent malaria and negative malaria microscopy. Detection of the Plasmodium a...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-4-56
更新日期:2005-12-01 00:00:00